The paper, through desk a review of literature aims to explore the underpinnings of feminization of HIV/AIDS and their linkages to Millennium Development Goals (MDGS). Findings indicate that: many women than men are infected by HIV/AIDS; feminization of poverty largely informs feminization of HIV/AIDS; societies embrace the myth that HIV/AIDS is a woman’s disease; and care giving is predominantly carried out by women. The following are suggested strategies to redress feminization of HIV/AIDS: Forming a men’s only sector to mobilize men to expedite response; working to dilute patriarchy; and embracing gender swap, gender readjustment and gender realignment.