Definition
Malaria exposure level in the geographic area where the site is situated. The InterVA-4 “high” (value='H') malaria setting was used for all the West African sites, plus the East African sites (with the exceptions, on the grounds of high altitude, of Nairobi, Kenya and Kilite-Awlaelo, Ethiopia), on the basis of local experience. All other sites used the “low” (value='L') setting; the “very low” setting was not used. The InterVA-4 guideline is that the “high” setting is appropriate for an expected malaria CSMF higher than about 1%, though the setting chosen does not result in any great dichotomisation of outputs; the clinical equivalent would be a physician’s knowledge that his/her current case comes from a setting where malaria is more or less likely, irrespective of particular symptoms