This study examined socioeconomic differentials of tobacco consumption and its effect on illicit drug use among rural men, extracting data from the 2004 Bangladesh Demographic and Health Survey. Overall, 58.4% of the respondents consumed tobacco either by smoking or chewing. Smoking bidi (33.9%) and cigarette (23.6%) were the most prevalent forms of tobacco use. The prevalence of illicit drug use was 3.5%. The predominant illicit drug used was ganja (2.3%). Socioeconomic and behavioral factors such as age, education, religion, marital status, premarital and extramarital sexuality, and having STDs were found to be significantly (P < .001) associated with tobacco consumption. Multivariate logistic regression analyses yielded significantly (P < .001) increased risk of illicit drug use for different forms of tobacco consumption, for young age, premarital and extramarital sexuality, and non-Muslims. Appropriate measures should be undertaken to prevent smoking and illicit drug use for a healthy Bangladesh.