The Seribu Islands are located in the Java Sea about 50 km northwest of Jakarta, Indonesia. The islands and surrounding waters support tourism, fishing and mariculture, transportation, waste disposal, mining, energy production, and environmental protection. Mariculture has become an important fisheries component since its products are highly valued and command good prices on the export market. However, mariculture sites, mostly located close to the 14 inhabited Seribu Islands, may potentially conflict with tourism and have become an issue in the development of the area. A Decision Support System (DSS), based on optimization of physical, chemical, and socioeconomic parameters to determine suitable locations for mariculture, is presented in this article.