The objectives of this research were to identify the characteristics and effectiveness of chemistry teaching programs that increase students’ entrepreneurial attitudes, chemistry concepts understanding and creativity. The research design application refers to the R & D (Research and Development) Design. Seventy-three senior high school students were involved in this research. The research data were collected through questionnaire, test, interviews and field notes. The data analysis used descriptive and inferential statistics. It has been concluded that: (1) the chemistry teaching program consists of laboratory activities, classroom activities, products-making activities, presentations, mind map activities and written tests. These activities are believed to develop students’ leadership and self-confidence and direct them to task and result-oriented, future, risk-taking and originality-oriented. The evaluations in this program consist of self-assessment, peer assessment and teacher assessment; (2) the program has developed students’ entrepreneurial attitudes, creativity and chemistry concepts understanding; (3) teachers and students responded the program positively; and (4) the implementation of the program shows that it takes much time. Based on the conclusions, it was suggested that: (1) the mind mapping activity should be carried out individually; (2) promotion program should be expanded so that students know the needs of the society; (3) further research should be done to find out whether this program can be conducted on lower grades and other topics of chemistry, biology and physics; and (4) further research should be conducted in various areas, such as in mountainous and beaches, so that the products will use the natural resources of the areas.