This study seeks to examine the role or impact of an individual’s ethnicity in relation to their interest in using contraceptives in Ghana. The study observes how gender affects the relationship between ethnicity and contraception use in Ghana. This study employs a data with the sample size of 11,888 from the 2008 Demographic and Health Survey (DHS) on Ghana. The dependent variable of the student is contraceptive usage and the independent variable of the study is ethnicity. The paper controls for gender and education, to determine the role of gender and education in relation to the dependent and independent variable. The results from the study proves that ethnicity strongly influence contraceptive use in Ghana. The study also proves gender also has a strong influence on contraception use in Ghana. In relation to education, the paper proves that persons with Primary, Middle/JSS/JHS and higher education-above Secondary/SSS/SHS school education have a strong relationship with contraceptive use in Ghana.