The study was carried out to ascertain how poverty, inequality and economic marginalization affect Ghana’s ability to meet its obligations under articles 11, 12 and 13 of the International Covenant on Economic, Social and Cultural Rights (ICESCR). The study examined the state obligations with respect to the above articles of the ICESCR and assessed the government performance in relation to its obligations under article 13 of the ICESCR. The study revealed that poverty and inequality in Ghana have important spatial and gender dimensions. The existence of poverty, inequality and economic marginalization in Ghana has profound implications for government’s capacity to meet its obligations under the relevant provisions of the ICESCR.