The effects of climate change on people’s livelihoods are perceived differently across various localities. It is imperative to examine how farmers understand the effects of climate change on their livelihoods. Their viewpoints can help create strategies for responding to climate and ecosystem changes in an appropriate and practical manner. Such perceptions are insufficiently understood in the Wa West District of the Upper West Region of Ghana, despite the increasing frequency and magnitude of climate change’s effects. This paper first examines farmers’ perceptions about climate change in their communities in relation to available, conventional climate information. It also assesses farmers’ livelihood activities during both the wet and dry seasons in the district and discusses the area’s proneness to floods, droughts, and other types of climate change phenomena. This assessment reveals the challenges faced by the farmers in the study area and the opportunities to enhance their livelihoods.