Background. Anemia in children continues to be a major public health challenge in most developing countries, particularly in Africa. Anemia in the early stages of life leads to severe negative consequences on the cognitive as well as the growth and development of children, which may persist even after treatment. We examine the prevalence of anemia in under-five children in the Ghanaian population to help inform and serve as a guide to health policies and possible interventions. Methods. Data from the 2008 Ghana Demographic and Health Survey (GDHS) was used. Data consists of health, demographic and socio-economic factors. Anemia status was determined using hemoglobin level, and prevalence of childhood anemia along with 95% confidence intervals was provided. We also examined the distribution of prevalence across different age and socio-demographic groups as well as the different regions and sub-regions in Ghana. Results. The overall prevalence of anemia in under-five children in Ghana was 78.4% (N?=?2168, 95% CI: 76.7-80.2), where 7.8% (N?=?2168, 95% CI: 6.6-8.9) of the children had severe anemia, 48.0% (N?=?2168, 95% CI: 45.9-50.2) moderate anemia and 22.6% (N?=?2168, 95% CI: 20.8-24.4) had mild anemia. The highest prevalence regions were the Upper East, 88.9% (N?=?158, 95% CI: 80.9-94.0), and Upper West 88.1% (N?=?220, 95% CI: 76.4-94.6). The prevalence was also higher among children under 2 years of age, 85.1% (N?=?781, 95% CI: 82.6-87.7) than children 2–5 years of age, 74.8% (N?=?1387, 95% CI: 72.5-77.1). No significant difference in prevalence between boys and girls was observed. Conclusions. Given the high prevalence of childhood anemia observed in Ghana, particularly among those less than 2 years old, and given the negative consequences on their cognitive and behavioral development even in later years, there is an urgent need for effective and efficient public health interventions.