This study is meant to address the determinants of the participation of persons with disability in the national agenda process with regard to economic development. It is also to examine the issue as to whether entrepreneurship is a viable career option for persons with disability in Ghana. The researcher made use of the mixed method, that is, both qualitative and quantitative research methods. In terms of qualitative data, they were obtained through focus group discussions while in the case of the quantitative data, the researcher made use of self-administered questionnaire which comprised close-ended and open-ended questions. The major findings of the study, among others, were non-development of hidden talents of persons with disability, a situation amounting to neglect of skill training in different areas, including entrepreneurship; non-recognition of persons with disability as stakeholders in society and also inadequate knowledge about disability due to lack of adequate data on disability issues.