The Livelihood Empowerment Against Poverty (LEAP) programme is a social protection measure that employs conditional cash transfer as a means of investing in human development to benefit the poor. LEAP includes conditionalities, which are intended to encourage poor households to prioritize the human capital development of the beneficiaries. This study examined compliance with the conditionality that LEAP beneficiary households have to register with the National Health Insurance Scheme (NHIS). The study involved primary data collection with 62 respondents in four communities of the Yilo Krobo District. The data was subjected to regression analysis to determine the relationship between NHIS compliance among low income (extremely poor) households and the size of household, age of household head and education of household head (independent). NHIS registration compliance was the dependent variable. Results from Pearson Correlation analysis showed that there exist no significant correlation between NHIS compliance and age of household head, and education of household head. However, there existed a positive relationship between size of household and NHIS enrolment compliance.