This is a qualitative study based on the testimony of directors of organizations addressing HIV/AIDS and people living with HIV/AIDS in the Dominican Republic. Although the manifestations of stigma and discrimination related to HIV/AIDS have decreased in the Dominican Republic in comparison to past decades, ignorance and lack of supervision from government authorities foster that people with HIV do not receive adequate health services and the protection of their right to employment. Some groups are more affected than others as a product of the reinforcement of existing prejudices in the Dominican society, such as antihaitianism. Facing the changes in the spread of the epidemic I propose some reflections on gender and HIV, and suggest how to reinforce existing positive initiatives and the adoption of new ones.