The population of the Ugandan capital, Kampala, located close to Lake Victoria, appears to be exposed to risk of ingesting the heavy metals Cadmium (Cd) and Lead (Pb) through vegetables in their diet. Lake Victoria is responsible for frequent torrential polluted runoffs in the city. The Nakivubo channel, the city’s major wetland drainage system, empties directly into the lake. Vegetables are grown on the urban wetland soils. Heavy metal content in vegetables from the wetland cultivation sites was determined by wet acid digestion, with 87–92% recovery. The results showed that although the heavy metal levels of manganese (Mn), zinc (Zn), cadmium (Cd) and lead (Pb) were significantly higher than those in similar food crops from rural control sites, only Cd and Pb exceeded the World Health Organisation (WHO) maximum permissible levels. Cd and Pb pose serious human health risks. Early pollution control measures are advisable.