This study examined the case of Uganda’s The AIDS Support Organization (TASO) services and changes in their clients’ sexual behavior. This study used statistical analyses to investigate the relationship between socio-demographic characteristics of the general population and of TASO clients and correlate patterns of sexual behavior with use of TASO centers. The first step of the analysis described the frequencies and proportions of the following variables within the TASO data set: Sex, Age, and Employment. It was then determined by use of a ratio equation Z-test if the proportion of each category of the TASO data set differed from the proportion in the same category of the national AIDS data and the national census of the general population. Analysis for examining TASO client changes in safe-sex behavior, utilized data collected between May and August of 1997. Analysis of socio-demographic characteristics found that high-risk groups among the TASO population appeared to be females in their late twenties and employed. Analysis of case studies revealed that during the course of long term TASO care, 25 percent of patients changed their behavior from unprotected sex to abstinence. The findings of this study supported the importance of TASO’s approach to care as a means of increasing safe-sex behaviors among HIV/AIDS patients.