Genetic structure of seven Mexican indigenous populations based on five polymarker loci

Type Journal Article - American journal of human biology
Title Genetic structure of seven Mexican indigenous populations based on five polymarker loci
Author(s)
Volume 15
Issue 1
Publication (Day/Month/Year) 2003
Page numbers 23-28
URL http://www.researchgate.net/profile/Ricardo_Cerda-Flores/publication/10929595_Genetic_structure_of_s​even_Mexican_indigenous_populations_based_on_five_polymarker_loci/links/02bfe50eb4dfd50db3000000.pdf
Abstract
This descriptive study investigates the genetic structure of seven Mexican indigenous populations (Mixteca Alta, Mixteca Baja, Otomies, Purepecha, Nahuas-Guerrero, Nahuas-Xochimilco, and Tzeltales) on the basis of five PCR-based polymorphic DNA loci: LDLR, GYPA, HBGG, D7S8, and GC. Genetic distance and diversity analyses indicate that these Mexican indigenous are similar and that more than 96% of the total gene diversity (HT) can be attributed to individual variation within populations. Mixteca-Alta, Mixteca-Baja, and Nahuas-Xochimilco show indications of higher admixture with European-derived persons. The demonstration of a relative genetic homogeneity of Mexican Indians for the markers studied suggests that this population is suitable for studying disease-marker associations in the search for candidate genes of complex diseases.

Related studies

»