Contagious Caprine pleuropneumonia (CCPP) is a devastating disease of goats caused by Mycoplasma capricolum subsp. Capripneumoniae (Mccp). The disease was first confirmed in Uganda in 1995 in Karamoja region. CCPP disease negatively impacts on goat health and production but its extent and magnitude among the local communities remains unknown. A cross sectional study was conducted in the districts of Agago and Otuke neighbouring Karamoja region in Northern Uganda during the months of July and August 2011 to explore the status of CCPP. A semi-structured questionnaire was administered to 162 selected farmers in the study areas to assess their knowledge, attitudes and perceptions on the factors they associated with CCPP occurrence and 8 focus group discussions were also conducted to obtain qualitative information on CCPP. Four hundred and four goats from randomly selected unvaccinated herds and 100 goats from vaccinated herds were examined for antibodies against Mycoplasma capricolum subsp. Capripneumoniae (Mccp) using ELISA.