Disasters are the coincidences between hazardous events, elements at risk, and conditions of vulnerability. Vulnerability integrates social and environmental systems to reduce the intensity and frequency of these risks. By categorizing regions according to their level of vulnerability, one can examine and assess the possible impacts of developmental and environmental degradation processes. This study is an attempt to map the sub-national areas (districts) in India that are vulnerable to natural and climate-induced disasters. The assessment is considered under the framework of Intergovernmental Panel on Climate Change definition of vulnerability. Using analytical hierarchy process as a multi-criteria decision-mapping method, vulnerability is measured in terms of exposure, sensitivity, and adaptive capacity. Based on this mapping assessment, districts in the state of Arunachal Pradesh, Assam, Bihar, Himachal Pradesh, Jharkhand, Manipur, Meghalaya, Mizoram, Uttar Pradesh, Uttarakhand, and West Bengal are the most vulnerable regions; while districts in the state of Punjab, Haryana, Gujarat, Tamil Nadu, Maharashtra, Goa, Andhra Pradesh, Kerala, and Karnataka are among the least vulnerable regions. The results of this study can serve as the basis for targeting prioritization efforts, emergency response measures, and policy interventions at district level for mitigating disaster vulnerability in the country.