Patterns of antiepileptic drug use and seizure control among people with epilepsy in a suburban community in southeast Nigeria

Type Journal Article - African Journal of Neurological Sciences
Title Patterns of antiepileptic drug use and seizure control among people with epilepsy in a suburban community in southeast Nigeria
Author(s)
Volume 31
Issue 2
Publication (Day/Month/Year) 2012
Page numbers 36-42
URL http://www.ajol.info/index.php/ajns/article/download/90493/79914
Abstract
Background
Epilepsy is characterized by episodic and unpredictable seizure recurrences which are often amenable to medical
treatment. Simple and readily available medications can be used to control seizures in epilepsy. However, in many
communities in developing countries seizure control among people living with epilepsy is still poor.
Method
We assessed the patterns of antiepileptic drug use and seizure control among persons living with epilepsy in a
suburban community in Southeast Nigeria found in a two phase cross-sectional study. Detailed information on
epilepsy treatment, seizure control and patterns of antiepileptic drug use (AED) by those diagnosed with epilepsy
was determined by use of a semi-structured interviewer administered questionnaire. Further verification of the type of
antiepileptic drugs (AEDs) was done by drug inspection.
Result
The total of 29 cases of active epilepsy comprising 16 (55.2%) males and 13 (44.8%) females were found. Those
receiving AEDs at the time of survey were 7 (24.1%), 11(37.9%) who had previously used AEDs had stopped and
the remaining 11 (37.9%) were AEDs naïve. Carbamazepine monotherapy was used by 57.1% (n=4) while
phenobarbitone was used by 42.9% (n=3). The antiepileptic drugs were prescribed in all these cases by medical
personnel. Over 82% of the persons with active epilepsy found were having more than one seizure per month.
Conclusion
Active epilepsy was prevalent in this suburban community with only 24.1% (n=7) of them receiving treatment with
AEDs. Seizure control was poor even among those receiving AEDs and carbamazepine monotherapy was most
commonly used AEDs.

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