The sustainability of rural livelihoods in the face of climate variability and change in developing countries like Zimbabwe remains debatable. Climatic conditions adversely affect agriculture which is the main rural livelihood in Chadereka Ward I of Muzarabani Rural District making its sustainability limited to a greater extend. The purpose of the study was to assess rural livelihoods in terms of their sustainability in Chadereka Ward I of Muzarabani Rural District in Zimbabwe. In order to accomplish the study, both qualitative and quantitative research approaches employing key informant interviews, focused group discussions, review of literature and household interview questionnaires were used in data gathering. The sustainable livelihood framework was used in the analysis of the data. Besides assessing the sustainability of the rural livelihoods practised in the area, the study further sought to identify challenges faced by households in Chadereka Ward I in an attempt to adapt to climate variability and change. The results of the study revealed that flood recession cultivation of maize (Zea mays L. or mudzedze in Shona), gathering of wild fruits such as (Zizphuas-mauritiana or masawu), cultivation of drought tolerant rain-fed crop such as sorghum (Sorghum bicolor) and livestock production are no longer fully sustainable according to the economic indicator for sustainability analysed in this research. The challenges faced include water scarcity, lack of constant institutional support, inaccessibility of the area during the rainy season, poor infrastructure and poor marketing services for their commodities. Finally, the roles played by major stakeholders in the area studied were established such as provision of food handouts, provision of agricultural input, early warning systems, provision of the indeginous knowledge system and the provision of educational material. The study implies that climate change phenomenon is now inevitable and people need to team up from local level especially at household level to find and implement adaptable ways for survival.