Background:
Helicobacter pylori (H. pylori) is a global pathogen with a widely varied prevalence (30%-80%) among different
countries and populations. This study aims to determine the prevalence of H. pylori in the population of Arak, Iran.
Materials and Methods:
This was an epidemiologic cross-sectional population-based study with multistage sampling. The population of
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urban and four rural Health Service Centers were randomly selected. The study population was divided between
these centers based on the population of individuals covered by these centers. Subsequently, clustered samples were
randomly chosen according to Health Care Unit Family Codes and the Right Hand Rule. After obtaining informed
consent and completion of a demographic questionnaire, 5 cc of venous blood was taken from each participant for
the H. pylori IgG antibody test. In this study IgG antibody against H. pylori was measured by ELISA.
Results:
Of 1187 participants, 1150 (853 urban and 297 rural) completed the study. Overall, 673 (58.5%) were positive for H.
pylori. The prevalence of H. pylori infection increased with age from 43.9% among those <20 years old to >70% in
participants over 50 years old (p=0.002). A total of 57% urban samples and 63.3% rural samples were H. pylori positive
(p=0.028). There was no relationship between H. pylori infection and education level (p=0.37), career (p=0.39)
and income, (p=0.29) in either the urban or rural areas [p=0.64 (education level), 0.48 (career), and 0.57 (income)].
Conclusion:
Our study showed a lower prevalence of H. pylori compared to some Asian countries, however this prevalence
was more common than Western countries. Using disinfected tap water in both urban and rural areas in addition to
improved access to general health care might have a role in this relative lower prevalence.
Keywords: Preval