A total of 400 ear swabs were collected from infant and children within the ages of 0-12years. All
samples were cultured on MCA, BA, CA, and SDA plates which yielded the following
Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Pseudomonas aeruginosa
Streptococcus species, Klebssiella spp, and Candida albicans. These bacteria isolates were
tested against selected antibiotics such as Tetracycline, Gentamycin, Ampiclox,
Chloramphenicol, Augmentin, Enthromycin, Cotrimoxazole and Ciprfloxacin, using Disc diffusion
method. Ciprofloxcin was the most sensitive antibiotic with Tetracycline and Chloramphenicol
being the least. The isolate antibiotic susceptibility was statistically significant by ANOVA
(P<0.05) which on further analysis with LSD and DMRT revealed that Ciprfloxacin isolate
sensitivity was significantly different to all the antibiotics while Gentamycin was statistically
significant over Tetracycline, Chloramphenicol and Cotrimoxazole. Furthermore, an overall
assessment of 75.43% sensitivity and 24.57% resistance respectively was observed which was
statistically significant by Chi square (P< 0.05) analysis. Isolates of C. albicans were tested
against selected orally administer antifungal agents such as Fluconazole, Ketoconazole,
Griseofulvin and Terbinafine using Microdilution tube method. Terbinafine was the most sensitive
and Fluconazole was the least. This study concludes that Ciprofloxcin and Terbinafine are the
most effective drugs of choice in first line treatment of Otitis media in children. Hence, for
effective management of cases a preceding mycology investigation should supplement
bacteriological diagnostic procedures.