Potable water supply in Ikare – Akoko, Nigeria has been on continuous decrease due to deficiency in
safe water supply infrastructure. The productive time of active labour force is being spent in sourcing
water due to distance of available sources. In recognition of these problems, this paper examines the
domestic water, sanitation and diarrhea situations among the five communities of Ikare – Akoko,
Southwestern, Nigeria. The study adopted the concept of Ecosystem Approach to Human Health (EcoHealth).
The research was conducted within trans-disciplinary protocol. As observed from the findings,
poverty and lack of education among gender especially women, have deprived the residents of all
communities particularly the indigenes the knowledge of environmental protection and health
awareness. The result also revealed that majority of residents depend on unsafe surface water as the
major domestic water supply source. About 80% of domestic activities that degraded habitable
environment are carried out indiscriminately. Wastes are disposed illegally within and around human
immediate environment. Most people used open space for defecation, while almost 90% of latrines are
open type and not well maintained. These have enhanced wide linkages between unsanitary
environment and human health which has really promoted and increased diarrhea cases.