The aim of this study was to investigate prevalence and potential risk factors of active trachoma in Gondar zuria district. Methods: Community-based cross-sectional study was conducted in Gondar Zuria District from December 1 to December 30, 2014. Multi stage random cluster-sampling technique was employed and all children 1-9 years old from selected household were clinically assessed for trachoma based on simplified WHO 1983 classification. A total of 597 children were included in this study. Data were collected by using semi-structured interview, pre-tested questionnaire and observation. EpiInfo 3.5.3 was used for data entry and cleaning, while IBM SPSS Statistics 20 was used for data analysis. A P-value <0.05 was considered statistically significant throughout this study. Result: The overall prevalence of active trachoma in this study was found to be 12.1%. The risk factors identified were age 1-5 years, low monthly income, poor perceived economy, infrequent face washing habit, not using soap during washing, absence of clean face, not using latrine, absence of waste disposal, and higher house hold fly density. On the other hand going to school was the only preventive factor identified in this study. Conclusion: The study result has shown the magnitude of active trachoma dropped from 76.5% to 12.1%, by 8 folds. This is dramatic decrement taking in to consideration the very large magnitude of the problem as of the base line data. WHO has leveled a cut of point for active trachoma to decide it is or not major public health problem. Based on this criterion, active trachoma is still a public health problem in the study woreda. So the woreda community at large and other responsible bodies should integrate each other to mobilize AFE strategy interventions by large.