This study analyzed the prospective relationship of community social disorder with sedentary behavior, sport participation, and adiposity in Mexican adults from the National Mexican Family Life Survey (MxFLS). The sample included 8307 adults (aged Z20 years) from 145 communities. During a three-year follow-up, participants from communities with high social disorder had a 1.36 cm larger increase in waist circumference than participants from communities with low social disorder. However, there were no differences in body mass index, television, or sport participation. These findings emphasize the need to promote healthy social environments in local communities.