The future of humanity in any part of the world is dependent upon the rate of infant’s survival at any given point in time. Many infants or neonates die out of avoidable diseases. Many infants across the globe are handled by their mothers; as such the knowledge of such mothers on the signs and symptoms of ill-health with regard to the infants is very important in curbing morbidity and mortality. Field data for this study was gathered from two sub-districts (an intervention and comparison communities) in the East Mamprusi District of the Northern Region of Ghana, using structured questionnaire. Results of the study, which sought to explore women knowledge of neonatal danger signs, revealed that many of the women have limited knowledge regarding neonatal danger signs. As far as the quality of antenatal care is concerned, it was observed that many of the women get the standard antenatal care as recommended by World Health Organisation. This study thus suggests that as part of health education and sensitization, women should be taken through danger signs prior to their discharge from hospital so that they can easily detect signs and rush to health care facilities as and when necessary.