This qualitative study investigated community and family members' perceptions and attitudes toward persons living with HIV/AIDS (PLWHAs) in rural Ghana and how PLWHAs viewed themselves. The purpose was to provide insights into the nature and extent of HIV/AIDS-related stigma for program and policy interventions. Interviews and focus group discussions examined the stigma. Seventy-four participants 18 years and above (60 community members, 10 PLWHAs, 2 family members of PLWHAs, and 2 HIV/AIDS counselors) participated. Results showed that PLWHAs experienced various forms of negative perceptions, were stigmatized by community and family members, and held strong negative views of HIV/AIDS, which negatively affected the way they lived. To reduce HIV/AIDS related stigma in rural areas, HIV/AIDS education programs that call for strong community and family member support for PLWHAs are essential.