Statistics across the globe show that HIV/AIDS infections and its consequences have become widespread and
difficult to deal with. Ghana though has had a decrease in infection of recent times, a more strategic approach
need to be adopted in order to completely eradicate the pandemic. Stigmatization and discriminatory attitudes
have been some of the reasons for the spread of the virus. In order to properly strategize against these attitudes
there is the need to identify the variables that influence people to stigmatize and discriminate against PLWHA.
This study therefore sought to find whether demographic independent variables such as gender, age, religious
denomination, settlement type, marital status, and the belief in the reality of HIV have significant effects on
stigmatization and discriminatory attitudes in terms of friendship, sex-mating, and marriage, as dependent
variables. Quantitative methods were employed using stratified sampling technique. Questionnaire was utilized
to solicit data. SPSS version 17 was used to analyze the data. Seven hypotheses were tested using Standard
Logistic Binomial and Multiple Regression. The study showed that, gender (0.012), religious denomination
(0.011), settlement-type (0.000), marital status (0.049) and belief that HIV is real (0.006), have significant
effects on students’ attitude on, at least, one of the dependent variables. When dependent variables were
combined, only the effects of belief that HIV is real (0.004), gender (0.025) and settlement-type (0.043) were
significant. The study recommends that in fighting against stigmatization and discrimination, education
campaigns and strategies should be holistic and multi-targeting in order to help eradicate the HIV/AIDS
pandemic.