Objective: To document ‘how international multilateral/bilateral donor agencies and nongovernmental organizations (NGOs) have undertaken, and commissioned or used health research in Zambia within the past five years’. Methodology Data were collected through one on one interview with international donors, NGOs, researchers from research institutions or organizations and through self administered questionnaire. Twenty five organizations were served with questionnaires. Out of these only eight responded to the questionnaire. A total of 54 operational research projects conducted between 2001 and 2006 were submitted either as reports or by completing the questionnaire. The papers were then analysed as to who sponsored them, at what cost, stage of execution, and the impact made to the health sector. One questionnaire was not included in the analysis because the researches were conducted outside the stated period. This report outlines how international donor agencies and NGOs have undertaken, commissioned and used operational health research in Zambia within the past five years. Main Findings of the Study The main findings were that all health research has been funded by the international donor agencies while the NGOs including public research institutions have been conducting health research. None of the multilateral responded to questionnaire. Among the bilateral donor agencies only one responded to the questionnaire including one International NGO. Thirty-nine percent of the research was focused on public health, 7% on clinical care, 11% on M&E and 39% on systems development.