Female genital mutilation (FGM) is an important issue of global interest. It has a direct effect on women’s health and violates their human rights. Millions of young women are affected by this harmful act especially in Africa and Middle Eastern countries. In Egypt, the overall prevalence of FGM or cutting (FGM/C) is 84.2%. Although a ministerial decree prohibited practitioners from performing it, it seems that law implementation had not affected the attitudes toward practice. Lack of knowledge about the consequences of FGM/C and cultural influences were the main reasons behind Egyptian physicians’ practice of FGM/C. Eradication of this bad ritual is a serious public health challenge. There is an urgent need for mass education of the nurses and general public to mobilize the community toward eradication of this act