Located at the North-East of Algeria, Constantine has an important administrative, economic, scientific and cultural position and knew a significant urban evolution during the different periods of its history. This city is located in active seismicity area of Algeria and has been stricken in the past by several moderate to strong earthquakes where the most recent took place on October 27th, 1985 with a magnitude Ms = 6.0. Because of its dense housing and high concentration of population (2374 hab/km²), Constantine presents a very high seismic risk which requires an assessment in order to take preventive measures to reduce losses in case of major event. In this context an earthquake scenario was performed using the HAZUS methodology adapted to the Algerian context and using a wide inventory of buildings built. The main results obtained from this scenario are presented in this paper.