This study was conducted to examine the cassava value chain and determine strategies for enhancing farmers' profitable participation in the chain, to reduce poverty in Tanzania. Data were collected from 98 farmers from three villages of Morogoro rural district. Profit and marketing margins along the cassava value chain were computed. A linear model was estimated whereby farm size, experience, total family labour, group participation, non-crop livelihood sources, and food insecurity were the main determinants of profitability. The emerging recommendation was for farmers' participation in profitable cassava value chain strands by strengthened coordination, improved cassava varieties, and enhanced agronomic practices and processing technologies.