Background: Nigeria is the most populous country in Africa. Worldwide the country has the second highest maternal mortality ratio. The fertility rate is 5.38 children per woman. Grand multiparity with its associated risks contributes to the high maternal mortality ratio. This study was conducted to find out the knowledge, attitude and practice of contraception among grand multiparous women attending the antenatal clinic in a specialist hospital, Kano. Methods: It was a descriptive cross-sectional study conducted among grand multiparous women attending antenatal care clinic at Murtala Muhammed Specialist Hospital, Kano from 1st September to 31st December 2013. All consenting grand multiparous women were recruited within the study period. Data were collected on a predesigned questionnaire and analysed using SPSS version 17 (SPSS Inc., IL, Chicago, USA). The descriptive statistics was used for categorical variables and Chi-square was used for test of significance. A P ≤0.05 was considered statistically significant for inference. Results: Three hundred and thirty four grand multiparas were recruited. The mean age was 37.23 ± 3.17 years. Majority of them (80.20%) got their contraceptive knowledge from the nurses and/or midwives. Up to 88.60% agreed have used contraceptives. The most popular and used contraceptive among the grand multiparous women was oral contraceptive pills (OCP) (89.80%). The major cause of the non-use of contraceptives was the fear of side effects (77.20%). Conclusion: Grand multiparous women mainly obtain their contraceptive knowledge from the nurses/midwives. OCP was the most used methods. Major causes of non-use of contraceptives were the fear of side effects and desire for more children.