Globally food shortage is still a problem for instance Africa, the most of popular region in the world still has the highest of under nourished. The probable answer to what are the factors influencing food shortage In Tanzania are not well known and documented. This study sought to assess the factors influencing the food shortage in Mtwara Mikindani Municipality by identifying factors influencing food shortage, determining the status of food availability and accessibility and finding out the possible measures to be taken in order to overcome the problem of food. Structured questionnaire, observation and Oral interview had been useful for collecting primary information in which the best recorded interviewees were analyzed supplemented by documentaries. Generally, this study concludes that food shortage in the study area is influencing by, climate change, bad tradition believe, poor government support, laziness culture, land degradation and infertility land. However, the government should not delay to implement its policies practically especially to the small producers so as to establish strong base on agriculture. Also, the government to employ as many as it can agricultural officers so as to allow farmers to get frequent visitors who will advise them on how to produce efficiently their products by using irrigation methods and scientific methods like the use of improved seeds.