Empirical studies on the impact of micro level intervention strategies on poverty among poor women in Botswana are lacking, yet women are a valuable asset for the economy of the country. Continued marginalization and disempowerment of women has become a serious problem which merit urgent attention. This article investigates the potential of the Grow Model in transforming the lives of 14 women who belong to the Kgopolano GROW Group in Molepolole, Botswana. Data was collected in May 2014 using primarily in-depth interviews and focus group discussions. The analysis utilized both content and thematic approaches. The results showed how the Grow Model has inspired women to empower themselves and self-transform into productive and prosperous lives. The results affirm the strength of the GROW model in promoting empowerment for social change in marginalized contexts. Key policy recommendations recognizes the limitations of the GROW model and build on its strengths.