Locomotor disability is one of the most commonly prevailing type of disability in India. This study was conducted with the aim of assessing the severity and to study the factors affecting progress of locomotor disability. A community based cross-sectional observation study was conducted in an urban slum of Mumbai. Total sample of 3665 individuals were screened; 205 were identified with locomotor disabilities who were subjected to a structured questionnaire and physical examination. The prevalence of locomotor disabilities is found to be 5.59 %. Females are affected more than the males and unemployment was observed to be very high. Awareness about rehabilitative services was found to be very low and very few individuals had ever taken any treatment. Majority of the individuals detected with locomotor disability were ambulatory, showed good IADL score and muscle power as well as single joint involvement. Advancing age and
longer duration of disability have been associated with low scores of IADL, low muscular power, multiple joint involvement and increased duration of disability. Treatment started at young age, on immediate diagnosis will halt the progress of the disease. Availability and awareness of rehabilitation facilities will go a long way in improving the quality of life of individuals with locomotor disabilities.