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Citation Information

Type Thesis or Dissertation - Master of Public Health
Title Factors contributing to mortality among HIV infected people on Isoniazid Preventive Therapy (IPT) in Botswana
Author(s)
Publication (Day/Month/Year) 2014
URL http://uir.unisa.ac.za/bitstream/handle/10500/13272/Mavis Thesis FINAL SUBMISSION 5 July 4330​6373.pdf;sequence=1
Abstract
The purpose of the study was to describe factors contributing to mortality among HIVinfected
people on Isoniazid Preventive Therapy (IPT) in Botswana. A quantitative,
explorative, descriptive study was used and 80 records of deceased IPT respondents
were reviewed through the use of a checklist.
The demographic factors, baseline physical examination, hospitalisation and drug
history were taken into consideration. Out of the deceased patients, 75% were female.
The major findings showed that 100% (N=80), the most highly indicated causes of death
were gastroenteritis (18.75%), cryptococcal meningitis (17.5%) andpneumonia
(16.25%). Of the patients (28.75%) who died before completing the six months of IPT.
The causes of death were gastroenteritis (21.7%), symptoms and signs of bacterial
pneumonia (17.4%), cryptococcal meningitis (13%), Pulmonary Tuberculosis (PTB)
(13%), septicaemia (13%), and murder (13%). It has been recommended that there
should be reorganisation of services of care for HIV-infected persons, such as provision
of Cotrimoxazole Prophylaxis Therapy (CPT) and Antiretroviral Therapy (ART) to ensure
holistic approach care. The future study should include HIV-infected children on IPT
using the same or modified objectives. The conclusion drawn was that disintegrated
interventions of IPT, CPT and ART and lack of holistic care for PLHIV lead to
opportunistic infections that caused mortality on patients on IPT

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