Incidences, trends and long term outcomes of retinoblastoma in three cancer registries, Thailand

Type Journal Article - Asian Pacific Journal of Cancer Prevention
Title Incidences, trends and long term outcomes of retinoblastoma in three cancer registries, Thailand
Author(s)
Volume 16
Publication (Day/Month/Year) 2015
Page numbers 6899-6902
URL http://europepmc.org/abstract/med/26514464
Abstract
Background: Retinoblastoma (RB) is rare, albeit the most common primary intraocular malignancy among
children. To elucidate the true incidence, trend and survival, we studied incidences and trends of retinoblastoma
in a large population with long-term follow-up using data from 3 population-based cancer registries. Objective:
To describe the incidence, trends and survival of RB between 1990 and 2009 in Khon Kaen, Songkhla and Chiang
Mai, Thailand. Materials and Methods: We sourced the data from the cancer registries in Khon Kaen, Songkhla
and Chiang Mai on children with retinoblastoma, diagnosed between 1990 and 2009. Retinoblastoma was defined
as per the International Classification of Disease for Oncology version 3 using the code 9510/3. Incidence was
analyzed using the standard method with the criteria of the International Association of Cancer Registries. The
Kaplan-Meier method was applied to calculate cumulative survival. Trends were calculated using the log rank
test. Results: We identified 75 cases of children between 0 and 15 years of age diagnosed with RB (Khon Kaen
31, Chiang Mai 20, Songkhla 24). Males and females were equally affected. The most common age group was
0-4 years. The morphological verification of the disease was 90.7%. The respective ASR in Khon Kaen, Chiang
Mai and Songkhla was 4.4, 4.0 and 4.6 per million; for which the overall ASR for all 3 areas was 4.3 per million.
The respective trend in incidence was 4, 2.8, 5.8 and 5.4 during 1990-4, 1995-9, 2000-4 and 2005-9. Overall,
incidence trended gradually upward by 2% annually. The respective survival rate in Khon Kaen, Chiang Mai
and Songkhla was 50, 40 and 75% (differences not significantly different at p=0.14) and the overall survival for
all centers was 60%. Conclusions: Over the last two decades, the incidence and overall survival of retinoblastoma
has increased. The ASRs and survival in Thailand were less than those in resource-rich countries.

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