In the recent decades, our world has been facing a series of communicable diseases
threats such as avian influenza, SARS, MERS-CoV, Ebola, Zika… Beside of the that, the
re-emergence of other communicable diseases still remains major burden for human. Hand,
foot and mouth disease (HFMD) is the ones that reported for long time ago. This disease is
an acute febrile illness in children with a papulovesicular skin rash at the palms or soles of
the feet, or both. Presentation can be with or without inclusion of mouth ulcers. HFMD can
result in severe complications such as encephalitis, aseptic meningitis, pulmonary edema,
myocarditis, and death (1). HFMD is caused by types of Enterovirus A species which
includes some Coxsackievirus A (CV-A) and Enterovirus A71 (EV-A71) (2), (3). The
transmission can be faecal-oral and respiratory secretions route by direct person-to-person
contact, droplets or fomites. Recent, the widespread community outbreaks of HFMD have
occurred mostly in Asia Pacific region with notable amount of cases and deaths. The
disease still has neither no specific treatment or vaccines so far.