The concept of poverty has gone beyond the monetary attributes to cover several dimensions directly influencing the level of individuals’ socio-economic status. Based on this methodological advancement, this study aims to approximate the deprivation of education, health and housing facilities to analyze the incidence of multidimensional poverty (MDP) at regional levels in the Sindh province of Pakistan. Findings revealed that the magnitude of MDP varies significantly across the regions due mainly to the variation in the deprivation levels of socio-economic aspects. Furthermore, the magnitude of MDP is higher in rural areas than urban areas in each region.