Child labor is pervasive across sub-Saharan Africa. A common assumption is that monetary poverty is its most important cause. The paper investigates this hypothesis with empirical evidence by exploring structural, geographic, monetary, demographic, cultural, seasonal and school-supply factors simultaneously that can affect child labor. It is a first attempt in the literature combining quantitative with qualitative methods to identify a much broader range of potential causes— on the demand- and supply-side and at the micro and macro levels—of why children work in agrarian economies like Ghana. Interviews with the Minister of Education and with children enrich the multivariate regression findings and identify interdependencies between schooling and child labor demand. The multiple causes of child labor include the country’s agricultural dependency, demographics and social norms, as well as the geographic isolation of Northern children and no returns to rural basic education. It also finds that child labor and schooling are likely to become substitutes rather than complements when children live in an agricultural household in the North and are males. Policy responses are outlined particularly on the demand-side that are needed to help mitigate harmful child labor that affects children’s education, with implications for similar agriculturally-dependent economies in sub-Saharan Africa.