The paper seeks to investigate whether increased access to microfinance by poor households in Ghana affects intra-household gender inequality and gender asset gap between male-headed households and female-headed households. The paper uses beta regression models and the Oaxaca decomposition to answer this question. The analysis is based on data obtained from household survey conducted in Ghana from May to July 2013. Comparative analysis of households with and without microfinance shows that on average female-headed households receiving micro-credit tend to spend equally on male and female children at the primary and secondary school levels whereas education expenditure is skewed in favor of male children relative to female children in the case of female-headed households without micro-credit. This result translates into higher years of schooling for children in female-headed households with micro-credit compared to their counterparts without micro-credit. On average, females in households receiving micro-credit have a higher share of household assets relative to females in households without micro-credit. The results from this paper suggest that microfinance helps to reduce intra-household gender inequality and gender asset gaps between male-headed and female-headed households.