Background: To contribute to a fuller appreciation of Ghana’s HIV epidemic, this paper presents various profiles of the Ghanaian HIV-affected household. To comprehensively tackle the HIV epidemic in Ghana, the profiles would provide stakeholders with ready information for policy formulation. Methods: We used data from a nationally representative survey that measured livelihood activities, household asset wealth, household composition, health, and nutrition variables of 1745 HIV-affected households. From these emerged various profiles. Results: About 50% of the households are headed by females. Households headed by men have an average size of three members, compared to two for female-headed households. There are far more AIDS widows than widowers. The annual death rate among the surveyed households was about 1000 per 100,000- households. Relatively more deaths occurred in male-headed households. Two-thirds of the households were asset poor. Various coping strategies were instituted by the households in reaction to threat of food insecurity. The national prevalence of chronic energy deficiency is 16%. Conclusions: Our data show that age of household head, hosting of a chronically ill member, and average size of household differed by sex of household head. The annual death rate of 1000 per 100,000 households is very high.