The aim of the researchers in this study was to examine the relations of paid work versus housework and educational level to metabolic syndrome in women. The study sample consisted of women who participated in a baseline survey of the Heart of Balcova Project, which is an ongoing cohort study in Izmir, Turkey. A randomly selected subsample of women who were aged 30–64 years and who were not retired or unemployed was derived from the individuals who participated in the Heart of Balcova Project. All data were collected through face-to-face interviews with 191 workers and 342 housewives. The association between employment status and metabolic syndrome was explored using multiple logistic regression models. The prevalence of metabolic syndrome was significantly higher among housewives than among workers. Among the women with a high educational level, odds of metabolic syndrome were significantly higher for housewives than for those who were employed. An association between employment status and metabolic syndrome was not observed in the group with a low level of education. The findings revealed that educational level had a modifying effect on the relationship between employment status and metabolic syndrome among women and thus has implications for improving the understanding of the importance of health and educational opportunities for housewives.