Pregnancy and childbirth are important stages in life because they are associated with social problems, mortality and morbidity of both mother and the child in low income countries. This study described knowledge, perceptions and practices that influence pregnancy, delivery and utilization of maternal health care services in Wakiso district central Uganda. This information is important in planning better maternal and child health care services. This was a qualitative study that utilized Focus group discussions (FGDs), Key informant interviews (KIs), and In-depth interviews. Seven Focus Group Discussions (FGDs) were held with mothers who had delivered in health units 5 years prior to the study, women who had come for ante natal care (ANC), and men who had fathered children 5 years and below. The key issues discussed were knowledge regarding and practices governing pregnancy and childbirth, the influence of knowledge on the delivery and utilization of maternal health care services and access to health care facilities. Twenty four key informant interviews were held with midwives, community leaders, traditional birth attendant (TBAs), and district health officials. Ten in-depth interviews, aiming at exploring problems associated with pregnancy and childbirth within their socio-cultural and economic contexts were conducted with women who had delivered 5 years prior to the study. Qualitative content analysis was done manually.