Natural hazards and major land-use/land-cover change can have significant impacts on humans around the world. If these two concerns exist together in a coastal area, the consequences for people and the environment may be severe. This study investigated the combined effects of land-use changes and natural disasters in the southwest coastal area of Bangladesh. Satellite images were analyzed to detect changes in land cover in the study period of 13 years (1999–2012). Three areas were selected for ground data collection. Household surveys and focus groups were conducted to discover the type, level and effects of disasters. Probit regression analysis was performed to assess the relationship between various disasters with overall income, agricultural production and outward migration. Results from image analysis showed an overall 30 % increase in shrimp culture ponds in the past 13 years. Agricultural land and vegetation decreased by 48 and 3 %, respectively. Barren and built-up areas increased by 73 % due to both land-use activity and natural hazards. Analysis of household data showed cyclones and storm surges had important effects on income, agricultural production and migration. Sustainable management and enhancement of resilience capacity of this area will be crucial in the near future.