The study was carried out in the south western agro-ecological zone (SWAEZ) of Uganda and it involved the districts of Bushenyi, Mbarara and Rakai. There is lack of information on the common medicinal plant extracts for poultry disease management in the SWAEZ. Also common poultry diseases and current management practices in the zone are not adequately documented. Yet, the typical village chicken farmers rely on medicinal plants in the control of Newcastle disease and helminthosis. A survey was conducted to establish an inventory of medicinal plants and the common poultry management practices used in the management of Newcastle disease and helminthosis. A total of 87 questionnaires were administered to poultry farmers. Veterinary extension workers were also involved for triangulation of information. The majority of the farmers (80%) were peasant farmers keeping on average 27 village chickens per household. The farmers had an average experience in poultry keeping of 2 to 3 years. About 45% of the farmers use traditional medicine, 37% use a combination of traditional and modern veterinary medicine while 17% use only modern veterinary medicine. There was a statistically significant relationship between the methods used to treat poultry diseases and the location (Bushenyi, Mbarara and Rakai) shown by (?2 = 13.965, P = 0.007); commercial feeding (?2 = 16.139, P= 0.000); commercial treatment for poultry (?2 = 16.471, P = 0.011); and prophylactic treatment of poultry diseases (?2 = 38.189, P = 0.058). The results of the multi nominal logistic regression analysis of the variables namely; district, feeding, vaccination, prophylaxis and government services provision were not significant. Although herbal drugs are used in the poultry disease management there are information gaps related to efficacy, safety, dosage and active substances of these plants. Information on these variables is unknown. It is therefore recommended that further research be undertaken on these research gaps.