The study was concerned with analysis of sanitation management in Makerere University and was carried out from the Department of Open and Distance Learning. Its major population included students, support staff and Administrators, while the sample comprised 15 respondents who involved cleaners, decision makers and students from the Department of Open and Distance Learning. Specifically the study investigated the institutional frame work, causes, challenges and strategies of sanitation management because of the need to establish better ways of proper sanitation management and waste disposal at Makerere University (Department of Open and Distance Learning). The study adopted an ethnography study design; while the data was collected by the way of interviews, observation and documentary analysis. The study was carried out from Open and Distance Learning because it was believed that the Department had a high population of students yet had four toilets shared by both students and Administrators. It took place from April to November 2011.