The article aims to show that small and medium enterprises (SMEs) and entrepreneurs is of great significance and play a crucial role in almost every nation’s economy and as such have become a major source of employment creation and income generation which induces innovation and economic growth. The SMEs sector is of specific importance for the development of the Republic of Moldova. Creating a business environment that fosters small business and entrepreneurship development in Moldova is a key to generating wider economic growth in the country. As entrepreneurship in Moldova represents a rather new definition and the entrepreneurial activity is very poor, in this context, the need for SMEs sector support through the creation of stable legal and economic conditions favoring entrepreneurial activity development is evident. Empirical research revealed main problems facing Moldovan SMEs, and their attitudes to entrepreneurship development.