In 2007, OECD released the scientific literacy assessment results of 57 countries/economies participating in the PISA 2006 main survey (OECD, 2007). Using Macao’s 15-year-old students’ responses to the questions in the student questionnaire, ten science quality education indicators composed of validated measurement scales were identified by Macau-PISA Center (Cheung and Sit, 2007). Because these quality indicators were reported to be statistically significantly correlated with students’ scientific literacy performance, it was worthwhile to make reference to them to inform policy makers and educational practitioners on directions of basic science education curriculum revision for the 15-year-olds in Macao. This paper sought to examine these directions considered worth-probing in Macao schooling contexts. The three directions identified were: (1) Further elevation of facilitative learning dispositions and practices, and it is particularly so for females; (2) Vitalization of self-efficacy and self-concept in science learning, for both males and females; and (3) Inculcating awareness, concern and optimism of environmental issues for all children enrolled in basic science education.