A crosscutting analysis of the six case studies and an examination of key issues and challenges related to education hub development are the focus of this chapter. The key themes for the comparative analysis include the planning approach (reactive, proactive, or strategic), the implementation model (fragmented, coordinated, strategic) to hub development, the driving rationales organized into major categories, the involvement of key policy sectors and influential actors, the perceived progress and accomplishments, as well as the impact on beneficiaries. The chapter closes with an analysis of the evolution and relationship among the three types of education hubs and questions whether there is a linear development from student to talent to knowledge type of hub.